Which of the following is a contraindication for Naloxone administration?

The use of Naloxone, an opioid antagonist, is primarily indicated in cases of opioid overdose, where its role is to reverse respiratory depression and other life-threatening effects caused by opioids. A known allergy to Naloxone is a significant contraindication for its administration, as administering a medication to someone who is allergic to it can provoke a severe allergic reaction, which may complicate the clinical situation and endanger the patient’s life further.

In contrast, known opioid use does not contraindicate Naloxone administration, as it is specifically intended to counteract the effects of opioids. Cardiac arrest and respiratory distress are also not contraindications for using Naloxone; in fact, Naloxone could be critical in these situations if they are due to opioid overdose. In summary, a known allergy to Naloxone is the only option that explicitly prevents its safe use in a clinical scenario.